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Related post: ralysis of the central nervous system and of the skeletal muscle-nerve endings. Poisoning is treated by tannin, evacuation Prazosin For Ptsd and stimulants. A bibliography is given in Cushny's ' ' Pharmacology . ' ' GELSEMIUM This, the root of Yellow Jasmine, acts similarly to nicotin and coniin. Its central depressant Order Prazosin action is relatively more marked (Cushny, 1892). It contains a crystalline alkaloid, Gelsemin, with weak strychnin action; and several amorphous alkaloids, Gelseminin and Gelsemo idin (C. W. Moore, 1910; Sayre, 1910 and 1912; Sayre and Chil- lingworth, 1914), which are chiefly responsible for the effects of the drug. " Gelseminin" Merck has been shown to consist of Gelsemin. Stevenson Prazosin Online and Sayre, 1915, describe a further alkaloid, "sempervirin." Uses. Gelsemium is employed against trigeminal and other neuralgias. This has no pharmacologic explanation. Even small doses sometimes cause toxic symptoms: giddiness, double vision, and slowing and arrest of respiration. Its local application to the eye dilates the pupil, Buy Prazosin with considerable irritation (Putzeys and Romie, 1887). It is no longer used as a mydriatic. Poisoning is treated by evacuation, atropin and stimulants. PREPARATIONS GELSEMIUM Gelsemium, U.S.P.; Gelsem. Rod., B.P. (Yellow Jasmine Root). The dried rhizome and root of Gelsemium sempervirens (nitidum, B.P.) Dase, 0.03 Gm., % gr. Ext. Gelsem., U.S.P. A powdered extract, i Gm. representing 4 Gm. of the drug. Dose, 10 mg., % gr., U.S.P. Fldext. Gelsem., U.S.P. Dose, 0.03 c.c., ^ minim, U.S.P. Tr. Gelsem., U.S.P., B.P. 10 per cent. Dose, 0.25 c.c., 4 minim, U.S.P.; 0.3 to I c.c., 5 to 15 minims, Purchase Prazosin Online B.P. 318 MANUAL OF PHARMACOLOGY SPARTEIN General Statement. This alkaloid has been used to slow the pulse in cardiac disturbances; but its effects are uncertain, it weakens the heart, and can not take Prazosin Hydrochloride the place of digitalis. Spartein is a pyridin derivative, like nicotin and coniin, and has similar actions (Fick, 1873). Its central effects are slight and its toxicity relatively low Ptsd Prazosin (GriffS, 1886, took 0.4 Gm., 6 gr., without bad effects, except slight confusion). Buy Cheap Prazosin It has no direct action on the Prazosin And Ptsd vasomotor center; but the depression of respiration tends to produce asphyxial stimulation (Pilcher and Sollmann, 1915). Peripherally, it has a fairly strong curare action, arresting respiration by paralyzing the phrenic endings (Cushny and Matthews, 1895). Larger doses also paralyze the respiratory center (Muto and Ishizaka, 1903). It has a weak local anesthetic effect (Guinard and Geley, 1894). No habituation could be induced in guinea pigs (Dorlencourt, 1913). Circulation. The experimental data give a confused picture of its actions. Small doses produce peripheral vagus paralysis (Fick and all subsequent workers). This may sometimes result in preliminary quickening of the pulse (Gluzinski, 1889) and removal of any vagus arythmias (Masius, 1887). The most constant feature is Prazosin Ptsd slowing of the pulse rate, which is not prevented by atropin, and is therefore due to direct depression of the cardiac muscle. Because of the slowing, the pulse waves appear large; but in contrast to digitalis, the tendency of the heart is diastolic instead of systolic (Cushny and Mat- thews). Frogs' hearts also Generic Prazosin show decrease of rate, strength and tone. With intravenous injections, the slowing becomes so extreme that it may be fatal; but this extreme action is of short duration, does not occur on oral administration, and is probably due to direct irritation of the endocardium. The blood pressure shows a progressive fall, explainable by the cardiac depression. Excised arteries are dilated (Cow, 1911). Rise of blood pressure has been reported but is of inconstant occurrence (Cerna, 1894), and is per- haps due to the mechanical effects of the injection and to asphyxia. Diuretic Effect. This has been affirmed and denied, clinically and experimentally (MacNider, 1910; Griff6, 1886). Its existence is very doubtful. Fronmueller, 1878, contended that the reputed diuretic effect of the parent plant (Scoparius) is due mainly to scoparin, a neutral principle. Uses. Order Prazosin Online Spartein was recommended by See, 1885; Laborde and Legris, 1886; and many others, in cardiac disease, valvular and functional, nervous palpitation, Graves' disease, asthma, etc. Clarke, Purchase Prazosin 1887, claimed that it produces marked slowing and strengthening of the pulse, the effect ap- pearing in thirty minutes and lasting for five to six hours. Perhaps more clinicians consider it useless (Leo, 1887; H. C. Wood). It is certainly devoid of the cardiac tonic action of digitalis ; and without this the slowing would be of little value. The influence of drugs on functional cardiac neuroses is difficult to judge. Atropin would be more efficient for paralyz- ing the vagi. Dosage. 10 Buy Prazosin Online mg., J^ gr., gradually increased to 0.13 Gm., 2 gr., every six to eight hours. A. Jacobi, 1907, advises not less than i gr. per day, even for babies. Overdoses produce nausea and vomiting. PREPARATIONS SPARTEIN *Sparteina Sulphas (Spart. Sulph.), U.S.P.; CisH^eNa.H^SO^ + sH 2 O. Hygroscopic colorless crystals or powder; odorless; slightly bitter. Freely sol. in water (i :i.i) or ale. (i 13). Dose, 10 mg., ^ gr., U.S. P. Maximum dose, 0.2 Gm., 3 gr. Scoparii Cacumina, B.P.; Broom Tops. The fresh or dried tops of Cytisus scoparius. Inf. Scopar., B.P. 10 per cent. Dose, 30 to 60 c.c., i to 2 ounces, B.P. Sticcus Scoparii (Succ. Scopar.), B.P.; Juice of Broom. The juice expressed from the fresh plant and preserved with one-third its volume of alcohol. Dose, 4 to 8 c.c., i to 2 drams, B.P. CURARE 319 CURARE General Statement. This is practically important in laboratory technic, for paralyzing the skeletal muscles through a selective depression of their nerve-endings, as shown in the classical researches of Cl. Bernard, 1857. It has no effect on sensory nerves and is not an anesthetic. It produces a number of side effects, resembling nicotin in depressing auto- nomic ganglia (vagus) ; and strychnin in stimulating the spinal cord. It may produce glycosuria. Intravenously, it causes a temporary fall of blood pressure, returning rapidly to normal with moderate doses. Death occurs by paralysis of the respiratory muscles; animals may be saved by artificial respiration, the drug being rather rapidly excreted by the urine. Curare is mutually antagonistic with physostigmin. It is much less toxic by the stomach, on account of slow absorption and rapid destruction and
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